| 基于秀丽隐杆线虫痴呆模型的络塞维抗阿尔茨海默病药效研究 |
| 投稿时间：2022-05-12 点此下载全文
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| 引用本文：梁丽娜,高雅婷,陈旭,刘永刚,张园园.基于秀丽隐杆线虫痴呆模型的络塞维抗阿尔茨海默病药效研究[J].中国现代中药,2023,25(1):58-63 |
| DOI：10.13313/j.issn.1673-4890.20220512002 |
| 摘要点击次数: 613 |
| 全文下载次数: 76 |
| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 梁丽娜 |
LIANG Li-na |
北京中医药大学 中药学院，北京 102488 |
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China |
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| 高雅婷 |
GAO Ya-ting |
北京中医药大学 中药学院，北京 102488 |
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China |
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| 陈旭 |
CHEN Xu |
北京中医药大学 中药学院，北京 102488 |
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China |
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| 刘永刚* |
LIU Yong-gang |
北京中医药大学 中药学院，北京 102488 |
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China |
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| 张园园 |
ZHANG Yuan-yuan |
北京中医药大学 中药学院，北京 102488 |
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China |
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| 中文摘要:目的 基于秀丽隐杆线虫（以下简称线虫）痴呆模型，探究络塞维抗阿尔茨海默病（AD）的作用及可能机制。方法 以转基因线虫CL4176为模型，在显微镜下考察络塞维对线虫瘫痪情况、寿命、运动能力、吞咽频率、活性氧（ROS）水平、抗氧化酶活力等指标的影响。结果 络塞维能够显著降低痴呆模型线虫瘫痪率（P<0.05），延长其寿命，增强其运动能力，显著提高其体内超氧化物歧化酶和过氧化氢酶的活力（P<0.05），显著降低其体内ROS水平和丙二醛含量（P<0.05）。络塞维对模型线虫的吞咽频率没有影响。结论 基于线虫痴呆模型，络塞维有抗阿尔茨海默病的作用，机制可能与改善氧化应激有关。 |
| 中文关键词:络塞维 抗氧化 秀丽隐杆线虫CL4176 阿尔茨海默病 |
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| Efficacy of Rosavin Against Alzheimer′s Disease: Based on Caenorhabditis elegans (CL4176) Model |
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| Abstract:Objective To explore the anti-Alzheimer′s disease (AD) effect and possible mechanism of rosavin with Caenorhabditis elegans.Methods Transgenic C. elegans CL4176 with AD was used, and the effect of rosavin on the paralysis, lifespan, mobility, pharyngeal pumping frequency, reactive oxygen species, and activity of antioxidant enzymes of C. elegans CL4176 was observed under the microscope.Results Rosavin can reduce the paralysis rate (P<0.05), prolong the lifespan, improve the mobility, increase the activity of superoxide dismutase and catalase (P<0.05), and decrease the reactive oxygen species and malondialdehyde content in the C. elegans CL4176 (P<0.05). It had no influence on the pharyngeal pumping rate of the nematodes.Conclusion It is demonstrated that rosavin showed anti-AD effect on C. elegans model, and the possible mechanism may have to do with improving oxidative stress. |
| keywords:rosavin antioxidation Caenorhabditis elegans CL4176 Alzheimer′s disease |
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