蜂胶化学成分、药理作用及临床应用研究进展
投稿时间:2022-03-28     点此下载全文
引用本文:王雨宵,常相伟,陈博文,汤毛毛,郭健,丁杨,陶曜天,桂双英.蜂胶化学成分、药理作用及临床应用研究进展[J].中国现代中药,2023,25(3):665-685
DOI:10.13313/j.issn.1673-4890.20220328001
摘要点击次数: 536
全文下载次数: 150
                       
作者中文名作者英文名单位中文名单位英文名E-Mail
王雨宵 WANG Yu-xiao 安徽中医药大学 药学院,安徽 合肥 230012 School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China  
常相伟* CHANG Xiang-wei 安徽中医药大学 药学院,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
现代药物制剂安徽省工程技术研究中心,安徽 合肥 230012
药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
道地药材国家重点实验室,北京 100700
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Engineering Technology Research Center of Modernized Pharmaceutics, Hefei 230012, China
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei 230012, China
State Key Laboratory of Dao-di Herbs, Beijing 100700, China
 
陈博文 CHEN Bo-wen 安徽中医药大学 药学院,安徽 合肥 230012 School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China  
汤毛毛 TANG Mao-mao 安徽中医药大学 药学院,安徽 合肥 230012 School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China  
郭健 GUO Jian 安徽中医药大学 药学院,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
现代药物制剂安徽省工程技术研究中心,安徽 合肥 230012
药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Engineering Technology Research Center of Modernized Pharmaceutics, Hefei 230012, China
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei 230012, China
 
丁杨 DING Yang 安徽中医药大学 药学院,安徽 合肥 230012 School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China  
陶曜天 TAO Yao-tian 安徽中医药大学 药学院,安徽 合肥 230012 School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China  
桂双英 GUI Shuang-ying 安徽中医药大学 药学院,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
现代药物制剂安徽省工程技术研究中心,安徽 合肥 230012
药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Engineering Technology Research Center of Modernized Pharmaceutics, Hefei 230012, China
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei 230012, China
 
基金项目:国家自然科学基金项目(81873019);中央本级重大增减支项目(2060302);安徽省高校科学研究项目(KJ2020A0415)
中文摘要:蜂胶是我国传统中药,具有补虚弱、化浊脂、止消渴的功效,外用可解毒消肿、收敛生肌。蜂胶中含有丰富的化学成分,目前已从蜂胶中分离鉴定出黄酮、酚酸、萜、糖、氨基酸、脂肪族、微量元素、维生素等类化学成分400余个,其中黄酮、酚酸、萜等类是其主要活性成分。现代药理研究表明,蜂胶具有抗炎、抗菌、抗病毒、抗氧化、治疗阿尔茨海默病、抗肿瘤、降血糖、调血脂、保肝、神经保护、免疫调节、促进伤口愈合、抑制黑色素生成等广泛的药理活性。临床上,蜂胶常用于治疗牙周炎、口腔溃疡、高脂血症、幽门螺杆菌感染、皮肤烧烫伤、鸡眼等疾病。查阅近20年来国内外蜂胶相关的研究报道,对其化学成分、药理作用及临床应用研究进展进行综述,以期为蜂胶的进一步研究开发与利用提供参考。
中文关键词:蜂胶  化学成分  药理作用  临床应用
 
Research Progress in Chemical Constituents, Pharmacological Effects, and Clinical Application of Propolis
Abstract:Propolis is a traditional Chinese medicine with the functions of tonifying deficiency, eliminating turbid, treating consumptive thirst, removing toxin, alleviating edema, astriction, and promoting granulation. Propolis is rich in chemical constituents. Up to now, more than 400 chemical constituents including flavonoids, phenolic acids, terpenoids, sugars, amino acids, aliphatics, trace elements, and vitamins have been isolated and identified from Propolis, among which flavonoids, phenolic acids, and terpenoids are the main active components. Modern studies have demonstrated that Propolis has anti-inflammatory, antimicrobial, antiviral, antioxidant, anti-Alzheimer's disease, antitumor, blood sugar- and lipid-lowering, hepatoprotective, neuroprotective, immunomodulatory, wound healing-promoting, and melanin production-inhibiting activities. Propolis has been widely used in the clinical treatment of periodontitis, oral ulcers, hyperlipidemia, Helicobacter pylori infection, skin burns, corns and other diseases. We reviewed the relevant research reports in recent 20 years and summarized the chemical constituents, pharmacological effects, and clinical application of Propolis, aiming to provide reference for the further research, development, and utilization of Propolis.
keywords:Propolis  chemical constituents  pharmacological effects  clinical application
查看全文   查看/发表评论  下载PDF阅读器