GC-IMS比较米泔水制苍术炮制过程中挥发性有机物的变化
投稿时间:2023-02-16     点此下载全文
引用本文:王奕博,张浩,任培芳,彭博扬,周旭,杜杰,陈彦琳.GC-IMS比较米泔水制苍术炮制过程中挥发性有机物的变化[J].中国现代中药,2023,25(12):2576-2582
DOI:10.13313/j.issn.1673-4890.20230216004
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作者中文名作者英文名单位中文名单位英文名E-Mail
王奕博 WANG Yi-bo 中国中药有限公司,北京 102600 China National Traditional Chinese Medicine Co., Ltd., Beijing 102600, China  
张浩 ZHANG Hao 山东海能科学仪器有限公司,山东 德州 251500 Shandong Haineng Scientific Instrument Co., Ltd., Dezhou 251500, China  
任培芳 REN Pei-fang 山东海能科学仪器有限公司,山东 德州 251500 Shandong Haineng Scientific Instrument Co., Ltd., Dezhou 251500, China  
彭博扬 PENG Bo-yang 中国中药有限公司,北京 102600 China National Traditional Chinese Medicine Co., Ltd., Beijing 102600, China  
周旭 ZHOU Xu 中国中药有限公司,北京 102600 China National Traditional Chinese Medicine Co., Ltd., Beijing 102600, China  
杜杰 DU Jie 中国中药有限公司,北京 102600 China National Traditional Chinese Medicine Co., Ltd., Beijing 102600, China  
陈彦琳* CHEN Yan-lin 中国中药有限公司,北京 102600 China National Traditional Chinese Medicine Co., Ltd., Beijing 102600, China  
中文摘要:目的 比较米泔水制苍术过程中挥发性小分子化合物的成分差异。方法 采用气相色谱-离子迁移谱法对苍术药材、生饮片、水制品、米泔水制品和家种苍术的挥发性有机物进行检测,采用直观比较及指纹图谱法对其进行比较和定性分析。结果 通过气味分析可明显区分苍术不同炮制品,明确定性的挥发性有机物有60个单体及部分化合物的二聚体、聚合物。壬醛、(E)-2-己烯醛、2-戊烯醛、3-甲基-2-丁烯醛和庚醛是苍术药材的特征性挥发性有机物;甲酸、乙酸甲酯是苍术饮片的特征性挥发性有机物;β-榄香烯、β-罗勒烯、柠檬烯、α-异松油烯和β-月桂烯是水制苍术的特征性挥发性有机物;3-甲基丁醛和2-甲基丁醛是米泔水制苍术的特征性挥发性有机物;乙偶姻、芳樟醇、异丁酸芳樟酯、α-松油醇是家种米泔水制苍术的特征性挥发性有机物;2-糠醛是苍术经热处理后的特征性挥发性有机物。结论 苍术不同炮制品挥发性有机物确有差异,米泔水的加入起到了减少萜类成分的作用,为更好地阐明经典名方中传统炮制方法原理提供参考。
中文关键词:苍术  米泔水制苍术  气相色谱-离子迁移谱法  挥发性有机物  炮制过程
 
Changes in Volatile Organic Components in the Processing of Atractylodis Rhizoma with Rice-washed Water Based on GC-IMS
Abstract:Objective To compare the differences in volatile small-molecule compounds in the processing of Atractylodis Rhizoma with rice-washed water.Methods Gas chromatography-ion mobility spectroscopy (GC-IMS) was used to detect the volatile organic compounds in medicinal materials, crude slices, water products, and rice-washed water products of Atractylodis Rhizoma, as well as cultivated Atractylodes chinensis. Visual comparison and fingerprinting analysis were employed for comparative and qualitative analysis.Results Through odor analysis, distinct differences were observed among different processed products of Atractylodis Rhizoma. Sixty monomers, as well as dimers and polymers of some compounds, were identified as definitive volatile organic compounds. Nonanal, (E)-2-hexenal, 2-pentenal, 3-methyl-2-butenal, and heptanal were characteristic volatile substances of Atractylodis Rhizoma medicinal materials. Formic acid and methyl acetate were characteristic volatile substances of Atractylodis Rhizoma slices. The β-elemene, β-ocimene, limonene, α-terpinolene, and β-myrcene were the characteristic volatile substances of water products of Atractylodis Rhizoma. The 3-methyl butanal and 2-methyl butanal were the characteristic volatile substances of rice-washed water products of Atractylodis Rhizoma. Acetoin, linalool, linalyl isobutyrate, and α-terpineol were the characteristic volatile substances of cultivated A. chinensis processed with rice-washed water. The 2-furfural was the characteristic volatile substance of Atractylodis Rhizoma after heat treatment.Conclusion Different products of Atractylodis Rhizoma indeed have variations in volatile organic compounds. The addition of rice-washed water reduced the terpenoid components, providing a reference for elucidating the principles of traditional preparation methods in classic herbal formulas.
keywords:Atractylodis Rhizoma  processed Atractylodis Rhizoma with rice-washed water  gas chromatography-ion mobility spectroscopy  volatile organic components  processing process
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