动物药多肽的药效学与分子鉴定研究进展
投稿时间:2023-10-07     点此下载全文
引用本文:叶聪,李国卫,胡绮萍,童培珍,罗宇琴,罗文汇,曲丽媛,孙冬梅.动物药多肽的药效学与分子鉴定研究进展[J].中国现代中药,2024,26(4):757-764
DOI:10.13313/j.issn.1673-4890.20231007006
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作者中文名作者英文名单位中文名单位英文名E-Mail
叶聪 YE Cong 广东一方制药有限公司,广东 佛山 528244
广州中医药大学,广东 广州 510405
Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528244, China
Guangzhou University of Chinese Medicine, Guangzhou 510405, China
 
李国卫 LI Guo-wei 广东一方制药有限公司,广东 佛山 528244 Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528244, China  
胡绮萍 HU Qi-ping 广东一方制药有限公司,广东 佛山 528244 Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528244, China  
童培珍 TONG Pei-zhen 广东一方制药有限公司,广东 佛山 528244 Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528244, China  
罗宇琴 LUO Yu-qin 广东一方制药有限公司,广东 佛山 528244 Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528244, China  
罗文汇 LUO Wen-hui 广东一方制药有限公司,广东 佛山 528244 Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528244, China  
曲丽媛 QU Li-yuan 广东一方制药有限公司,广东 佛山 528244 Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528244, China  
孙冬梅* SUN Dong-mei 广东一方制药有限公司,广东 佛山 528244 Guangdong Yifang Pharmaceutical Co., Ltd., Foshan 528244, China  
基金项目:广东省基础与应用基础研究基金项目(2020B1515120033)
中文摘要:动物药在传统医学领域占据着重要地位,经过数千年的实践在中国得到广泛应用,其临床应用和药理活性一直是研究的核心。其中,动物来源的蛋白质和肽被认定为其药理作用的重要物质基础。肽类药物有望成为国际药物研发的新热点,动物药因富含潜在药效活性肽而成为备受关注的“宝库”。通过综述现有相关文献,系统总结动物源药物中活性肽的药理功能研究进展。同时,介绍了常见肽的分析鉴定和发现方法,特别强调了液相色谱-质谱联用技术在研究动物源药物肽类成分方面的应用策略和现状,及其在动物源药物中的肽成分研究中显示出的独特优势。该技术在动物源药物真伪鉴别、质量控制及潜在活性肽的筛选等方面具有显著效果,为深入了解动物源药物的作用机制和推动肽类药物的发展提供参考。
中文关键词:动物药  活性肽  肽鉴定  液质联用  生物信息学
 
Research Progress on Pharmacodynamics and Molecular Identification of Active Polypeptides from Animal-derived Chinese Medicine
Abstract:Animal-derived medicines hold a significant position in traditional Chinese medicine, they have been widely practiced in China for thousands of years. The clinical application and pharmacological activity of these medicines have remained central topics of research. Among them, proteins and peptides derived from animals are identified as crucial molecular foundations for their pharmacological effects. Peptide drugs are poised to become a new focus in international pharmaceutical research, with animal-derived medicines attracting significant attention as a "treasure trove" due to their abundance of active peptides with potential therapeutic effects. This paper aims to systematically review existing literature, summarizing the recent advancements in the pharmacological functions of active peptides in animal-derived medicines. Additionally, common methods for peptide analysis, identification, and discovery are introduced, with a particular emphasis on the application strategies and current status of liquid chromatography-mass spectrometry (LC-MS) technology in studying peptide components of animal-derived medicines. Overall, LC-MS technology exhibits unique advantages in the research of peptide components in animal-derived medicines. This technology has significant impact in the identification of authenticity, quality control, and screening of potentially active peptides of animal-derived medicines, providing a reference for a in-depth understanding of the mechanisms of action of animal-derived medicines and the advancement of peptide-based drugs.
keywords:animal-derived medicine  active peptides  peptide identification  LC-MS  bioinformatics
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