中药虎杖研究进展及质量标志物(Q-Marker)预测
投稿时间:2024-01-31  修订日期:2024-02-29   点此下载全文
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作者中文名作者英文名单位中文名单位英文名E-Mail
侯淇允 houqiyun 天津中医药大学 Tianjin University of Traditional Chinese Medicine hou_qy@qq.com 
张林林 zhanglinlin 天津药物研究院 Tianjin Institute of Pharmaceutical Research zhangll@tipr.com.cn 
郝艳琦 haoyanqi 天津药物研究院 Tianjin Institute of Pharmaceutical Research haoyanqi@tipr.com.cn 
许浚* xujun 天津药物研究院 Tianjin Institute of Pharmaceutical Research xujuntj@163.com 
张铁军 zhangtiejun 天津药物研究院 Tianjin Institute of Pharmaceutical Research zhangtj@tjipr.com.cn 
基金项目:针对呼吸系统疾病的大品种中成药的现代化深度研究与开发
中文摘要:虎杖是我国常用的大宗中药材,资源丰富且分布较广,具有广阔的开发利用前景。虎杖中化学成分类型丰富,包括二苯乙烯类、醌类、黄酮类等化合物,虎杖的药理作用主要体现在抗炎、抗氧化、抗病毒、抗菌、抗癌、肝保护、心血管保护、免疫调节等方面。对其化学成分、药理作用综述的基础上,根据中药质量标志物(Q-marker)理论,从生源途径、化学成分有效性、化学成分可测性及不同配伍环境几方面对虎杖Q-marker成分进行预测分析,为明确虎杖Q-marker和制定科学的质量标准提供基础。
中文关键词:虎杖  质量标志物  蒽醌类  二苯乙烯类  质量控制
 
Progress and Q-marker Prediction Analysis of Traditional Chinese Medicine Polygonum cuspidatum
Abstract:Polygonum cuspidatum (P. cuspidatum) is a commonly used bulk traditional Chinese medicine (TCM) in China, with rich resources and wide distribution, and has broad prospects for development and utilization. P. cuspidatum has a wide range of chemical components, including stilbenes, anthraquinones, flavonoids and other compounds. The pharmacological effects of P. cuspidatum are mainly anti-inflammatory, antioxidant, antiviral, antibacterial, anticancer, liver protection, cardiovascular protection, immune regulation and so on. Based on the summary of its chemical components and pharmacological effects, and the theory of quality marker (Q-marker) of TCM, the Q-marker components of P. cuspidatum were predicted and analyzed from the aspects of the source of TCM, chemical component effectiveness, chemical component detectability and different compatibility environments, so as to provide a basis for clarifying the Q-marker of P. cuspidatum and formulating scientific quality standards.
keywords:Polygonum cuspidatum  Q-markers  anthraquinones  stilbenes  quality control
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