| 醋乳香现代研究进展及质量标志物的预测 |
| 投稿时间：2023-07-24 点此下载全文
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| 引用本文：张嘉慧,张林林,郝艳琦,许浚,张铁军.醋乳香现代研究进展及质量标志物的预测[J].中国现代中药,2024,26(2):240-251 |
| DOI：10.13313/j.issn.1673-4890.20230724001 |
| 摘要点击次数: 296 |
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| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 张嘉慧 |
ZHANG Jia-hui |
天津中医药大学，天津 301617 |
Tianjin University of Chinese Medicine, Tianjin 301617, China |
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| 张林林 |
ZHANG Lin-lin |
天津药物研究院 药物成药性评价与系统转化全国重点实验室，天津 300462
和光中药科技（天津）有限公司，天津 300301 |
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin Institute of Pharmaceutical Sciences, Tianjin 300462, China
Optochinese Medicine Technology (Tianjin) Co., Ltd., Tianjin 300301, China |
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| 郝艳琦 |
HAO Yan-qi |
天津药物研究院 药物成药性评价与系统转化全国重点实验室，天津 300462
和光中药科技（天津）有限公司，天津 300301 |
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin Institute of Pharmaceutical Sciences, Tianjin 300462, China
Optochinese Medicine Technology (Tianjin) Co., Ltd., Tianjin 300301, China |
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| 许浚* |
XU Jun |
天津药物研究院 药物成药性评价与系统转化全国重点实验室，天津 300462
和光中药科技（天津）有限公司，天津 300301
天津药物研究院 天津市中药质量标志物重点实验室，天津 300462 |
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin Institute of Pharmaceutical Sciences, Tianjin 300462, China
Optochinese Medicine Technology (Tianjin) Co., Ltd., Tianjin 300301, China
Tianjin Key Laboratory of TCM Quality Markers, Tianjin Institute of Materia Medica, Tianjin 300462, China |
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| 张铁军* |
ZHANG Tie-jun |
天津药物研究院 药物成药性评价与系统转化全国重点实验室，天津 300462
和光中药科技（天津）有限公司，天津 300301
天津药物研究院 天津市中药质量标志物重点实验室，天津 300462 |
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin Institute of Pharmaceutical Sciences, Tianjin 300462, China
Optochinese Medicine Technology (Tianjin) Co., Ltd., Tianjin 300301, China
Tianjin Key Laboratory of TCM Quality Markers, Tianjin Institute of Materia Medica, Tianjin 300462, China |
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| 基金项目:国家自然科学基金重点项目（81830111） |
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| 中文摘要:醋乳香是乳香Olibanum经醋炙法加工后的炮制品，炮制后可除去部分挥发油成分，消除其对胃黏膜的刺激性，同时能引药入经增强活血止痛、收敛生肌等功效。通过总结文献报道，从醋炙后化学成分与功效变化，刺激性研究，成分特有性、有效性、可测性，配伍环境及体内过程相关性等方面对醋乳香的质量标志物（Q-marker）进行预测分析，初步确定3-乙酰基-9,11-去氢-β-乳香酸、3-乙酰基-α-乳香酸、3-乙酰基-β-乳香酸、11-羰基-β-乳香酸、11-羰基-β-乙酰乳香酸5个三萜类成分和挥发油类成分乙酸辛酯为其可能的Q-marker，以期为醋乳香的全程质量评价、临床应用研究提供理论依据。 |
| 中文关键词:醋乳香 质量标志物 三萜类 二萜类 挥发油类 质量评价 |
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| Modern Research Progress of Vinegar Frankincense and Prediction of Quality Markers |
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| Abstract:Vinegar frankincense is the processed product of frankincense Olibanum processed by vinegar. After processing, part of the volatile oil components can be removed, and its irritation to gastric mucosa can be eliminated. At the same time, it can guide drugs into the meridians to enhance the effects of activating blood, relieving pain, and ensuring astringent muscle. By summarizing literature reports, the quality biomarkers (Q-markers) of vinegar frankincense were predicted and analyzed from the aspects of chemical composition and efficacy changes, irritation studies, component specificity, effectiveness, testability, compatibility environment, and correlation with in vivo processes after vinegar processing. Five triterpenoids, namely 3-acetyl-9,11-dehydro-β-boswellia acid, 3-acetyl-α-boswellia acid, 3-acetyl-β- boswellia acid, 11-carbonyl-β-boswellia acid, and 11-carbonyl-β-acetyl-boswellia acid, as well as octyl acetate, a volatile oil component, were preliminatively identified as possible Q-markers. The results may provide a theoretical basis for the whole-process quality evaluation and clinical application research on vinegar frankincense. |
| keywords:vinegar frankincense quality marker triterpenoids diterpenoids volatile oils quality evaluation |
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