| ICP-MS测定诃子炮制前后无机元素含量及安全性评价 |
| 投稿时间：2023-12-01 点此下载全文
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| 引用本文：李华爽,姜媛媛,余少君,叶婉婷,马涛,陶欧,刘永刚.ICP-MS测定诃子炮制前后无机元素含量及安全性评价[J].中国现代中药,2024,26(5):848-855 |
| DOI：10.13313/j.issn.1673-4890.20231201003 |
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| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 李华爽 |
LI Hua-shuang |
北京中医药大学，北京 100029 |
Beijing University of Chinese Medicine, Beijing 100029, China |
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| 姜媛媛 |
JIANG Yuan-yuan |
百济神州（北京）生物科技有限公司，北京 100022 |
Bei Gene, Ltd., Beijing 100022, China |
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| 余少君 |
YU Shao-jun |
北京中医药大学，北京 100029 |
Beijing University of Chinese Medicine, Beijing 100029, China |
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| 叶婉婷 |
YE Wan-ting |
北京中医药大学，北京 100029 |
Beijing University of Chinese Medicine, Beijing 100029, China |
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| 马涛 |
MA Tao |
北京中医药大学，北京 100029 |
Beijing University of Chinese Medicine, Beijing 100029, China |
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| 陶欧* |
TAO Ou |
北京中医药大学，北京 100029 |
Beijing University of Chinese Medicine, Beijing 100029, China |
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| 刘永刚* |
LIU Yong-gang |
北京中医药大学，北京 100029 |
Beijing University of Chinese Medicine, Beijing 100029, China |
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| 基金项目:国家自然科学基金重点项目（82130113） |
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| 中文摘要:目的 建立诃子生品及清炒、麸煨、砂烫、烘制4种炮制品中26个无机元素的分析方法，对其中重金属及有害元素进行健康风险评估。方法 采用电感耦合等离子体质谱法，以铑和铼为内标，通过标准曲线法测定诃子中的26个元素；采用危害指数（HI）法和暴露限值（MOE）法进行健康风险评估。结果 26个元素的标准曲线线性关系良好，仪器检出限为0.000 2~0.434 2 μg·kg–1，加样回收率为83.21%~116.84%。诃子炮制前后无机元素差异明显，部分重金属及有害元素所致健康风险较低。结论 该方法简便、准确，适用于诃子中无机元素的含量测定，为其重金属及有害元素健康风险评估提供了参考。 |
| 中文关键词:诃子 电感耦合等离子体质谱法 炮制 无机元素 重金属及有害元素 风险评估 |
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| Determination of Inorganic Element Content and Safety Evaluation of Terminalia chebula before and after Processing by ICP-MS |
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| Abstract:Objective A method was established to analyze 26 inorganic elements in raw products, stir-fried products without adjuvant, stir-fried products with bran, products scalded with sand, and baked products of Terminalia chebula. The health risk of heavy metals and harmful elements in T. chebula were assessed.Methods By using inductively coupled plasma-mass spectrometry (ICP-MS), the 26 elements were determined by the standard curve method with rhodium and rhenium as internal standards; the hazard index (HI) method and the limit of exposure (MOE) method were used for health risk assessment.Results The standard curves for the 26 elements exhibited excellent linear relationships, with instrumental detection limits varying from 0.000 2 to 0.434 2 μg·kg–1, and the spiked recoveries of 83.21%-116.84%. Notable distinctions in inorganic elements in T. chebula before and after processing were observed. Some heavy metals and harmful elements posed a low risk to human health.Conclusion The method is accessible, precise, and well-suited for determining inorganic element content in T. chebula, providing a reference for health risk assessment of heavy metals and harmful elements. |
| keywords:Terminalia chebula Retz. ICP-MS processing inorganic elements heavy metals and harmful elements risk assessment |
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