| 虎杖研究进展及质量标志物预测 |
| 投稿时间：2024-01-31 点此下载全文
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| 引用本文：侯淇允,张林林,郝艳琦,许浚,张铁军.虎杖研究进展及质量标志物预测[J].中国现代中药,2024,26(5):912-926 |
| DOI：10.13313/j.issn.1673-4890.20240131001 |
| 摘要点击次数: 228 |
| 全文下载次数: 0 |
| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 侯淇允 |
HOU qi-yun |
天津中医药大学，天津 301617 |
Tianjin University of Chinese Medicine, Tianjin 301617, China |
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| 张林林 |
ZHANG Lin-lin |
天津药物研究院 药物成药性评价与系统转化全国重点实验室，天津 300462
天津药物研究院 天津市中药质量标志物重点实验室，天津 300462
和光中药科技（天津）有限公司，天津 300301 |
National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin 300462, China
Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin 300462, China
Heguang Science and Technology of Traditional Chinese Medicine (Tianjin) Co., Ltd., Tianjin Institute of Pharmaceutical Research, Tianjin 300301, China |
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| 郝艳琦 |
HAO Yan-qi |
天津药物研究院 药物成药性评价与系统转化全国重点实验室，天津 300462
天津药物研究院 天津市中药质量标志物重点实验室，天津 300462
和光中药科技（天津）有限公司，天津 300301 |
National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin 300462, China
Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin 300462, China
Heguang Science and Technology of Traditional Chinese Medicine (Tianjin) Co., Ltd., Tianjin Institute of Pharmaceutical Research, Tianjin 300301, China |
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| 许浚* |
XU Jun |
天津药物研究院 药物成药性评价与系统转化全国重点实验室，天津 300462
天津药物研究院 天津市中药质量标志物重点实验室，天津 300462
和光中药科技（天津）有限公司，天津 300301 |
National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin 300462, China
Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin 300462, China
Heguang Science and Technology of Traditional Chinese Medicine (Tianjin) Co., Ltd., Tianjin Institute of Pharmaceutical Research, Tianjin 300301, China |
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| 张铁军* |
ZHANG Tie-jun |
天津药物研究院 药物成药性评价与系统转化全国重点实验室，天津 300462
天津药物研究院 天津市中药质量标志物重点实验室，天津 300462
和光中药科技（天津）有限公司，天津 300301 |
National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin 300462, China
Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin 300462, China
Heguang Science and Technology of Traditional Chinese Medicine (Tianjin) Co., Ltd., Tianjin Institute of Pharmaceutical Research, Tianjin 300301, China |
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| 基金项目:安徽省科技重大专项（202303a07020007） |
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| 中文摘要:虎杖是我国常用的大宗中药材，资源丰富且分布较广，具有广阔的开发利用前景。虎杖中化学成分类型丰富，包括二苯乙烯、醌、黄酮等类化合物，虎杖的药理作用主要体现在抗炎、抗氧化、抗病毒、抗菌、抗癌、肝保护、心血管保护、免疫调节等方面。在对其化学成分、药理作用综述的基础上，根据中药质量标志物（Q-marker）理论，从生源途径、化学成分有效性、化学成分可测性及不同配伍环境几方面对虎杖Q-marker进行预测分析，为明确虎杖的Q-marker和制定科学的质量标准提供参考。 |
| 中文关键词:虎杖 质量标志物 蒽醌类 二苯乙烯类 质量控制 |
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| Research Progress and Q-marker Prediction Analysis of Traditional Chinese Medicine Polygonum cuspidatum |
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| Abstract:Polygonum cuspidatum (P. cuspidatum) is a commonly used bulk traditional Chinese medicine (TCM) in China, with rich resources and wide distribution, and has broad prospects for development and utilization. P. cuspidatum has a wide range of chemical components, including stilbenes, anthraquinones, flavonoids and other compounds. The pharmacological effects of P. cuspidatum are mainly anti-inflammatory, antioxidant, antiviral, antibacterial, anticancer effects, liver protection, cardiovascular protection, immune regulation and so on. Based on the summary of its chemical components and pharmacological effects, and the theory of quality marker (Q-marker) of TCM, the Q-marker components of P. cuspidatum were predicted and analyzed from the aspects of the source of TCM, chemical component effectiveness, chemical component detectability and different compatibility environments, so as to provide a basis for clarifying the Q-marker of P. cuspidatum and formulating scientific quality standards. |
| keywords:Polygonum cuspidatum Sieb. et Zucc. Q-markers anthraquinones stilbenes quality control |
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