蛇葡萄属药用植物亲缘学研究
投稿时间:2023-10-16     点此下载全文
引用本文:曾铁鑫,许利嘉,宋颜君,马培,陈之端,肖培根.蛇葡萄属药用植物亲缘学研究[J].中国现代中药,2024,26(6):978-988
DOI:10.13313/j.issn.1673-4890.20231016004
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作者中文名作者英文名单位中文名单位英文名E-Mail
曾铁鑫 ZENG Tie-xin 中国医学科学院 北京协和医学院 药用植物研究所,北京 100193
教育部中草药物质基础与资源利用重点实验室,北京 100193
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China
 
许利嘉 XU Li-jia 中国医学科学院 北京协和医学院 药用植物研究所,北京 100193
教育部中草药物质基础与资源利用重点实验室,北京 100193
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China
 
宋颜君 SONG Yan-jun 中国医学科学院 北京协和医学院 药用植物研究所,北京 100193
教育部中草药物质基础与资源利用重点实验室,北京 100193
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China
 
马培 MA Pei 中国医学科学院 北京协和医学院 药用植物研究所,北京 100193
教育部中草药物质基础与资源利用重点实验室,北京 100193
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China
 
陈之端 CHEN Zhi-duan 中国科学院 植物研究所 系统与进化植物学国家重点实验室,北京 100193 State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing 100193, China  
肖培根* XIAO Pei-gen 中国医学科学院 北京协和医学院 药用植物研究所,北京 100193
教育部中草药物质基础与资源利用重点实验室,北京 100193
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China
 
基金项目:中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-031);国家科技基础资源调查专项(2018FY100700);广西科技基地和人才专项(AD22080012)
中文摘要:蛇葡萄属(Ampelopsis Michaux)植物为多年生木本藤蔓植物,全世界有30余种,中国有17种,大部分为中国特有,多具有传统药用价值,可作茶饮。基于系统进化关系和形态学相似性,近期蛇葡萄属中具羽状复叶的种从该属中分出,成立牛果藤属(Nekemias Raf),但这需要更多证据,特别是植物化学方面的证据支持。对蛇葡萄属植物亲缘关系、化学成分和药理活性进行归纳总结,并对其药用亲缘学进行探讨。蛇葡萄属中含有丰富的黄酮类化合物,但其主要种类存在差异,具羽状复叶的蛇葡萄种富含二氢杨梅素、杨梅素等类黄酮物质,而其余蛇葡萄属植物则检测到了白藜芦醇、儿茶素等酚酸类物质。这些化合物具有抗肿瘤、保肝、抗菌等活性,可与传统功效相关联。对蛇葡萄属植物的药用亲缘关系进行初步探讨,可为该属植物的资源保护和进一步开发提供参考。
中文关键词:蛇葡萄属  化学成分  传统功效  药理活性  药用植物亲缘学
 
Pharmacophylogenetic Relationship of Ampelopsis
Abstract:Ampelopsis Michaux is a genus of perennial woody vine encompassing roughly 30 species globally, of which approximately 17 are found in China, with the majority being endemic. Historically, most species of this genus have been revered for their medicinal properties, extensively consumed as therapeutic tea beverages across various ethnic groups. Recent taxonomical assessments, underpinned by phylogenetic relationships and morphological criteria, have led to the delineation of the species possessing pinnate compound leaves from Ampelopsis, subsequently categorizing them into a new genus termed Nekemias. Yet, corroborative evidence, particularly from phytochemical analyses, remains paramount. This study delves into the genetic affinities, chemical profiles, and pharmacological properties of Ampelopsis. Notably, while the plants of this genus are prolific in flavonoids, different species showcase distinct chemical constituents. For instance, those with pinnate compound leaves predominantly contain flavonoids such as dihydromyricetin and myricetin, whereas other species have phenolic acids like resveratrol and catechin. These chemical compounds demonstrate anti-tumor, hepatoprotective, and antimicrobial activities, resonating with traditional medicinal uses. Probing into the pharmacophylogenetic relationship of Ampelopsis helps to pave the way for conservation and therapeutic potential enhancement of plants belonging to this genus.
keywords:Ampelopsis Michaux  chemical constituents  traditional medicinal uses  pharmacological activity  pharmacophylogeny
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