| 定量核磁共振技术在中药质量控制中的应用进展 |
| 投稿时间：2023-09-06 点此下载全文
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| 引用本文：姚佳敏,孙巍,熊皓舒,章顺楠.定量核磁共振技术在中药质量控制中的应用进展[J].中国现代中药,2024,26(6):1099-1110 |
| DOI：10.13313/j.issn.1673-4890.20230906003 |
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| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 姚佳敏 |
YAO Jia-min |
中国药科大学 中药学院，江苏 南京 211198
天士力医药集团股份有限公司 中药先进制造技术国家地方联合工程实验室，天津 300410 |
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
National＆Local United Engineering Laboratory for Traditional Chinese Medicine Advanced Manufacturing Technology, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China |
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| 孙巍* |
SUN Wei |
天士力医药集团股份有限公司 中药先进制造技术国家地方联合工程实验室，天津 300410
现代中药创制全国重点实验室，天津 300410 |
National＆Local United Engineering Laboratory for Traditional Chinese Medicine Advanced Manufacturing Technology, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China
National Key Laboratory of Chinese Medicine Modernization, Tianjin 300410, China |
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| 熊皓舒 |
XIONG Hao-shu |
天士力医药集团股份有限公司 中药先进制造技术国家地方联合工程实验室，天津 300410
现代中药创制全国重点实验室，天津 300410 |
National＆Local United Engineering Laboratory for Traditional Chinese Medicine Advanced Manufacturing Technology, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China
National Key Laboratory of Chinese Medicine Modernization, Tianjin 300410, China |
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| 章顺楠 |
ZHANG Shun-nan |
天士力医药集团股份有限公司 中药先进制造技术国家地方联合工程实验室，天津 300410 |
National＆Local United Engineering Laboratory for Traditional Chinese Medicine Advanced Manufacturing Technology, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China |
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| 基金项目:工业和信息化部现代中药智能制造示范工厂项目 |
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| 中文摘要:中药质量控制是保证中药安全有效、质量稳定的基础，是中药标准化、现代化、国际化的前提，选用合适的分析方法在中药质量控制中具有重要意义。与薄层色谱、气相色谱、高效液相色谱等常规分析方法相比，定量核磁共振技术（qNMR）样品前处理简单、分析检测速度快、无需自身对照品，集定性鉴别和定量分析于一体，适用于中药中各类成分的检测分析，或将作为一种有力的分析技术，应用于中药质量控制。对qNMR的基本原理、定量方法和药典应用进行总结，重点介绍了qNMR在中药材、中药制剂、中药对照品及中药生产过程质量控制中的应用进展，提出了qNMR存在的若干问题并展望了其发展前景，旨在为采用qNMR控制中药质量提供参考。 |
| 中文关键词:中药 质量控制 定量核磁共振技术 含量测定 研究进展 |
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| Research Progress in Application of Quantitative Nuclear Magnetic Resonance in Quality Control of Traditional Chinese Medicine |
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| Abstract:Quality control of traditional Chinese medicine (TCM) is the foundation for ensuring the safety, efficacy and quality stability of TCM and the premise for the standardization, modernization, and internationalization of TCM. It is thus of great significance to select an appropriate analysis method in the quality control of TCM. Compared with thin-layer chromatography, gas chromatography, high performance liquid chromatography and other conventional methods, quantitative nuclear magnetic resonance (qNMR) is suitable for the analysis of various components in TCM. This method can be used as a powerful tool for the quality control of TCM due to its convenient sample preparation, short measurement time, no need of reference substances, and integration of qualitative identification and quantitative analysis. This paper introduces qNMR regarding the basic principles, quantitative methods, and applications in Pharmacopoeia and reviews the research progress of qNMR in the quality control of Chinese medicinal materials and the preparations, reference substances, and the production process of TCM. Moreover, this paper points out existing problems and envisions the prospects of qNMR, aiming to provide a theoretical basis and technical support for the application of qNMR in the quality control of TCM. |
| keywords:traditional Chinese medicine quality control quantitative nuclear magnetic resonance content determination research progress |
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