桑源中药保健食品的组方规律及质量控制分析
投稿时间:2024-03-05  修订日期:2024-03-16   点此下载全文
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作者中文名作者英文名单位中文名单位英文名E-Mail
张茜茜 ZHANG Qian-qian 北京市药品检验研究院 国家药品监督管理局创新药物安全研究与评价重点实验室 Beijing Institute for Drug Control, NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drugs zhangqianqian09413@163.com 
彭玉 PENG Yu 北京市药品检验研究院 国家药品监督管理局创新药物安全研究与评价重点实验室 Beijing Institute for Drug Control, NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drugs Pengyu_1221@126.com 
林超 LIN chao 北京市药品检验研究院 国家药品监督管理局创新药物安全研究与评价重点实验室 Beijing Institute for Drug Control, NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drugs 812027603@qq.com 
李雪梅 LI Xue-mei 北京市药品检验研究院 国家药品监督管理局创新药物安全研究与评价重点实验室 Beijing Institute for Drug Control, NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drugs lixuemei@bidc.org.cn 
曹春然* CAO Chun-ran 北京市药品检验研究院 国家药品监督管理局创新药物安全研究与评价重点实验室 Beijing Institute for Drug Control, NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drugs chunrancao@bidc.org.cn 
基金项目:国家重点研发计划(2018YFC1706802)
中文摘要:目的:探讨不同桑源中药保健食品的组方规律并分析其质量控制现状。方法:构建桑源中药保健食品数据库,对其保健功能进行统计,运用频数、性味、归经、功效、关联规则等分析主要保健功能组方规律,结合文献分析其质量控制现状。结果:桑源中药保健食品中,以有助于增强免疫力、缓解体力疲劳的桑椹保健食品和以有助于维持血糖健康水平的桑叶保健食品为主。在有助于增强免疫力的桑椹保健食品中,代表性组合为桑椹-黄精-黄芪;在缓解体力疲劳的桑椹保健食品中,代表性组合为桑椹-山药-覆盆子;在有助于维持血糖健康水平的桑叶保健食品中,代表性组合为桑叶-玉竹-山药;三类桑源中药保健食品的功效成分/标志性成分均涉及总皂苷、粗多糖、总黄酮。结论:桑源中药保健食品的组方规律研究可为产品研发提供思路,其质量控制成分的研究有待深入,同时桑白皮、桑枝保健食品开发力度有待增强。
中文关键词:桑源中药  保健食品  组方规律  质量控制
 
Analysis on formula regularity and quality control of health food containing mulberry source Chinese medicine
Abstract:Objective: To explore the formula rules of different mulberry source Chinese medicine health food and analyze their quality control status. Method: Databases of health food containing mulberry source Chinese medicine were established. Their health functions were counted. The frequency, nature, taste, meridian tropism, efficacy and association rules were used to summarize the formula rules. And their quality control status was analyzed based on the literatures. Result: Among the mulberry source Chinese medicine health food, Mori Fructus health food that enhance immunity and relieve physical fatigue and Mori Folium health food that maintain blood sugar health level accounted for a large percent. In Mori Fructus health food that enhance immunity, the representative combination is Mori Fructus- Polygonati Rhizoma- Astragali Radix; In Mori Fructus health food that relieve physical fatigue, the representative combination is Mori Fructus- Dioscoreae Rhizoma- Rubi Fructus; In Mori Folium health food that maintain blood sugar health level, the representative combination is Mori Folium- Polygonati Odorati Rhizoma- Dioscoreae Rhizoma; The functional components of the three types of mulberry source Chinese medicine health food all involve total saponins, crude polysaccharides, and total flavonoids. Conclusion: The study on formula regularity of mulberry source Chinese medicine health food can provide ideas for product development. Further research is needed on the quality control components, and the development of Mori Cortex and Mori Ramulus health food needs to be strengthened.
keywords:Mulberry source Chinese medicine  health food  formula rule  quality control
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